Evolutionary breeding, just like weeds

September 2022

Despite all the toxins, genetic devices, and shear physical destruction we throw at them, pests of all kinds continue to thrive in our fields. As climate change imposes all manner of unusual stresses on the environment, farmers and their crops struggle, while pests go from strength to strength.

It's not too difficult to see why. 

Herbicide tolerant GM soya is insecticidal too

June 2022

Glyphosate-tolerant GM crops aren't something that usually bring insecticides to mind.  Indeed, historically, US soyabeans were only sporadically challenged by insect pests.  Things changed around 2000 with the arrival of the soybean aphid which can only be controlled by foliar spraying.  Hot on the heels of this pest invasion came dramatic increases in bean leaf beetle which prompted the US Environmental Protection Agency (EPA) to issue an emergency exemption for neonicotinoid insecticidal seed treatments. 

GM crops adding to ecosystem collapse

June 2022

A key selling-point for 'Bt' insecticide-generating GM crops is that they reduce the need to spray chemical pesticides on the crop. It is claimed this makes them 'environmentally-friendly'.

Indeed, a study published in 2014, which combined data from 147 studies world-wide, showed a significant 42% reduction in the quantity of pesticide applied on Bt crops compared to conventional ones. This was much hyped as proof of the benefits of GM in agriculture by the pro-GM lobby and by the UK government committee which reported it. The study was, however, narrowly focused on comparisons of the weight of pesticide applied in kilograms per hectare or per year. Pre-emptive systemic insecticides, put on the seed but not sprayed onto the crop in the field, were not factored in.

GM - an unsustainable, pro-rich technology

May 2022

Indian farmers first embraced GM cotton in 2002. 'Bollgard' cotton with its very own 'Bt' insecticide-generating gene, was heralded as a sustainable, pro-poor technology which would provide substantial benefits to smallholders. It promised reduced pest-damage, reduced chemical treatments, and increased yields.

In a country which contributes a quarter of global cotton, and has seven million smallholder farmers, Bollgard was a silver bullet to combat a key pest.

Within five years, however, the silver bullet was getting tarnished and the pests on cotton were ignoring it. Enter Bollgard II with two varieties of Bt toxin generated at higher levels and combatting more pests.

Breeding Bt crops breeds healthy pests

May 2022

In the first decade of 'Bt' insecticidal GM maize growing, it was noted that aphids unexpectedly thrived on them. Aphids are sap-sucking insects which can reproduce prodigiously under the right conditions, but don't usually cause economic damage to maize crops. It was suggested that these overwhelmingly 'right conditions' in the Bt maize plants might be their slight, but significantly, increased levels of amino acids*, dismissed by regulators as of 'no biological significance'.

Weak skinned Bt plants with Bt unfriendly viruses

May 2022

'Bt' insecticide-generating GM crops are sold as a major weapon in the battle against key species of pest without the need for chemical applications.

The initial benefits of Bt are eroded within a few years, not only by the evolution of resistance in the target pests, but by Bt-resistant non-target pests which are happy to fill the vacant seat at the monoculture banquet.

Early on, we had reports of out-of-control mealy bugs on Bt crops in India and Pakistan [1] and mirid bugs in China [2]. These are assumed to be the result of reduced spraying with broad-spectrum insecticides thanks to Bt.

However, there are some much more complicated environmental interactions going on. For example, mirid bugs were previously minor pests on cotton until the Bt GM version came along.

Super toxic Bt cowpeas

May 2022

In 1990, Monsanto scientists published their latest discovery about the new 'Bt' insecticides generated by GM crops which were soon to become every farmers 'must-have'.

Their exciting finding, with an "immediate commercial implication" was that the insecticidal power of Bt could be increased many fold if its degradation was prevented by the plant itself. Many plants produce substances which prevent the breakdown of proteins, such as the Bt toxin, possibly to keep herbivores at bay by interfering with their digestion. The authors suggested this would confer "significant and long-term implications and benefits" on Monsanto's "genetically improved" Bt-generating plants.

Safety assessment of the new Bt crops was based on two strands of evidence.

GM cotton in India

February 2022

Once upon a time in India, farmers grew indigenous ('desi') Asiatic cotton.

Desi cotton was grown in multi-cropping systems which provided back-up crops if one of them failed. It could be planted at a high density to increase yield and had a short season which reduced pest exposure. This traditional cotton had good tolerance to biotic and abiotic stresses, including bollworm, saline conditions and drought. Today, the crop accounts for less than 3% of the cotton area in India.

GM wheat in Argentina

February 2022

In 2004, the US, Canadian and European wheat markets breathed a sigh of relief when Monsanto yielded to pressure and withdrew its glyphosate-tolerant GM wheat from the pipeline.

Predictably, it was just a matter of time before GM wheat popped up again, this time as 'HB4' with combined drought-resistance and tolerance to glufosinate herbicide.

HB4 has now been approved by Argentina: no surprise there, because the country has long been a key route used by the agrichemical industry as a bridgehead to the rest of Latin America for the (legal and illegal) dissemination of its products.

Gene edited 'healthy' bread

January 2022

One elusive, and potentially very lucrative, holy grail long pursued by the biotech industry is GM wheat. Not just any GM wheat of course, but one which is acceptable to consumers and to their food suppliers.

Realising that the ace to play in winning over a biotech-sceptical public could well be the anti-cancer card, the US market is being sounded out using gene-edited potatoes designed not to give you cancer [1] and cancer-busting GM purple tomatoes [2]. In the UK, the government is forging ahead with a field trial of gene-edited wheat which they claim, like the GM spuds, won't give us cancer. 

2,4-D on the menu too

October 2021

If you've just been reading about the two latest GM-crop-linked, cancer-causing herbicides to add to the glyphosate formulations already in use globally [1,2,3,4], don't relax, here's another one to worry about.

Last year, China approved Corteva's* 'Enlist' GM soya for importation. This secured a place for Enlist crops, plus the herbicide 2,4-D they're designed to be sprayed with, in US fields. It was described by GM seed suppliers, MS Technologies, as "great news for US soybean growers".

*Corteva Agriscience is a division of DowDupont

A former research professor who now works as a consultant for environmental groups said "2,4-D could by-pass glyphosate as the most widely used pesticide within a couple of years".

2,4-D and its sister chemical, 2,4,5-T, were two of several substances developed by Britain and America as herbicidal weapons during World War II. These two were formulated for use in equal quantities and were later packed in colour-coded containers to become known as 'Agent Orange'.

Isoxaflutole - The Next Herbicide Headache?

October 2021

In the 1990s, agrichemical giant, Bayer, was developing its own herbicide/GM-crop package to compete with Monsanto's hugely successful glyphosate and 'Roundup Ready' GM soya. However, as part of the Bayer-Monsanto merger deal, the company was required to off-load this product. The outcome, approved for the market in 2020, was isoxaflutole-resistant GM soya now produced by its new owner, BASF.

Isoxaflutole is a newcomer in the world of herbicides and is recognised as a probable human carcinogen because it induces liver and thyroid tumours in rodents. This herbicide is potentially toxic to the liver, blood and eyes, and may have negative developmental effects. It's pretty good at drifting, and is persistent and mobile in the environment, possibly accumulating in ground water.

All this may sound like a good reason not to approve isoxaflutole nor the GM crops designed to escalate its use. 

Dicamba - Worse Than Glyphosate

October 2021 

 

After all the whitewashing of glyphosate herbicide revealed when its manufacturer, Monsanto, was taken to court by users who now have cancer [1], it should come as no surprise that dicamba herbicide [2] looks like being a re-run of the same story.

The Glyphosate Cancer Lag Phase is over

September 2021

Cancer is, without doubt, one of the most devastating of modern diseases. Treatment is limited and unpleasant, and prevention is difficult because of the biology of cancers.

Cells become cancerous when physical and/or chemical stressors disturb gene function to the point where the normal protective cell repair and rebalancing mechanisms are overwhelmed. The prevention problem arises because there isn't one single cause, but rather a whole raft of contributing factors which combine in complex ways to trigger the disease of the cell. For example, exposure to stressors at a low intensity for a long time may cause cancer just as surely as a high dose of the same stressor for a brief period. A variable lag phase, ranging from months to decades makes identifying the cause of any cancer particularly tough.

All these complications are bad news for people whose food, water, air and environment are laced with potentially carcinogenic agrichemicals. They're even worse news for the people whose job it is to spray the world with these chemicals. However, they're excellent news for agrichemical and biotech companies who don't want any evidence that their top moneyspinners may be guilty of causing cancer.

Glyphosate is damaging our children

September 2021

 

Glyphosate-based herbicides have become ubiquitous in our food chain and in our environment. Their presence has been boosted, especially, by GM glyphosate-tolerant commodity crops such as soya, maize, sugar-beet, cotton, and oil-seed rape.

How much damage are these herbicides doing to our children? Even before they've been born? And even threatening their very existence?

Epigenetic mayhem courtesy of glyphosate

September 2021

 

Epigenetics are defined as 'molecular factors and processes around DNA that regulate genome activity, independent of DNA sequence, and are. stable (during cell division)'. They regulate gene activity by turning specific genes on and off.

So far, at least five epigenetic processes have been identified, including chemical groups which attach to DNA or to the RNA expressed by the DNA, besides structural effects on the chromosome. Such processes are reversible, but can also be passed down through many generations.

The epigenome (totality of epigenetics) plays a key role in health and disease. Individuals (animals or plants) are the outcome of the integrated actions of all the epigenetic processes they have inherited or acquired during their life-time.

Known causes of epigenetic changes which are passed on to the next generation in humans include environmental toxins, nutrition, stress and smoking.

Scientists in the Center for Reproductive Biology in Washington State University have carried out an experiment which suggests that glyphosate herbicide could be a significant contributor to the current escalating incidence of chronic disease. If they're right, it means that we're still near the beginning of that wave of disease which will continue to surge for the next two generations and beyond, unless we do something about it.

Herbicide headache II

March 2020

"...we used to sit next to the neighbours in church on Sunday. We don't even want to be in the same congregation with them anymore" (Ruff). This is what the latest GM soya is doing to the US farming community.

Just as biotech giant, Bayer, is coming to grips with the glyphosate lawsuits it acquired when it bought Monsanto in 2018 [1], it's finding itself with another herbicide headache.

The first of several suits against BASF (makers of older brands of dicamba herbicide) and against Bayer (makers of dicamba-tolerant GM soya seed and the dicamba formulations to go with them) came to court in January [2].  Compensation sought is $20.9 million plus punitive damages.

Blaming the activists

March 2020

Once upon a time (actually 2012), the Westminster Government launched a GM spin offensive on the UK public. The tactic was to make GM a 'hot topic' which kept popping up in the news, despite nothing having actually happened. Part of this strategy seems to have employed the talents of writer and speaker Mark Lynas [1].

Lynas' qualifications are in history and politics, but he writes and speaks about science. He seems to be a man who needs the glamour and theatre of a cause to champion, and in his youth was happy to join anti-GM crop activists in 'decontaminating' GM field trials (or one at least, by his own account). He has even been, in his own words "accused of having been the global founder of the anti-GMO movement".

However, creeping around the countryside dressed in black on a dark night isn't glamorous or theatrical. Nor is unlawful activity lucrative for someone who earns his living from writing. (It's also been suggested Lynas' comrade crop-trashers didn't like him very much.) There's much more mileage for a talented writer in declaiming the excesses of biotech industry PR, and sharing in the bounty of its deep pockets. So, he swapped sides and devoted himself "pretty much full time to the GMO issue".

Glyphosate on the plate

March 2020

Food-related uses of glyphosate-based herbicides in a nutshell:

The vast majority of commercial GM food crops - including maize, soya, canola, sugar-beet and cotton (consumed as cotton-seed oil) - are glyphosate tolerant and therefore sprayed with glyphosate-based herbicides. Applications of the herbicide on these crops have been stepped up year-on-year due to evolving weed resistance.

Besides GM crops, glyphosate-based herbicides are used as a pre-harvest desiccant on wheat, barley, oats (and other grains), sugar cane, lentils, beans, peas, chickpeas, sunflower, mints, potatoes and cantaloupe.

Glyphosate on the road

March 2020

After the World Health Organisation's International Agency for Research on Cancer (IARC) concluded there's enough robust scientific evidence to consider glyphosate herbicide "probably carcinogenic to humans" [1], Edinburgh and Barcelona City Councils announced their intention to take action [2].

Edinburgh commissioned a report on the options and costs of alternative weed control methods such as special blow-torches, hoeing and hot water.  Barcelona was looking at a ban on the herbicide in favour of a sustainable, ecological style of management for its gardens.

Four years later, where have these flagship initiatives led?