March 2022
"Even with the complete genetic information of a synthetic micro-organism, it is beyond the capacity of any existent bioinformatic analysis to fully predict the capability of a synthetic organism to survive, colonise and interact with other organisms under natural conditions, given the uncountable diversity of potential microhabitats and their temporal variability." (European Food Safety Authority, 2020)
By "synthetic micro-organism" is meant GM bacteria, GM fungi and GM yeast*. In their natural form all of these are a permanent feature inside, on and around higher plants and animals where they interact with each other and with their host to play a vital role in health and disease.