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Unhealthy healthy soya oil

December 2021


In a curious chain of reductionist science, assumption, generalisation, extrapolation and failure to investigate ambiguous data, the western diet shifted from traditional, saturated animal fats to novel unsaturated vegetable oils in the space of a very few decades. Studies in the 1950s and 1960s linked the saturated fats in a typical American animal-based diet to increased risk of cardiovascular disease. This led to a dogma that all saturated fats are unhealthy and so, conversely, all unsaturated fats are healthy. Similarly, this logic extended to whatever is healthy for the heart is healthy for the rest of the body too.

As a result, soyabean oil has moved from having a negligible presence in the diet to constituting more than 60% of the edible vegetable oil which people are now eating instead of animal fats. Key to this shift, were US government subsidies to soya growers which helped soya to become a leading commodity crop. These subsidies later enabled the adoption of GM Roundup Ready soya in American agriculture too.

Soya oil is now ubiquitous in modern processed foods, margarines, salad dressings and snack foods, and is the oil of choice in many restaurants and fast food establishments.

Bad laboratory practice

December 2021

In the 1970s, there was a massive scandal when America's largest contract research laboratory, responsible for a third of all its pre-approval toxicology testing, was found to have been manipulating studies and systematically falsifying experimental data for over a decade. 

Industrial Bio-Test Laboratories (IBT) carried out around a third of US pharmaceutical and chemical product safety testing during the 1950s, 1960s and 1970s.

When the Food and Drug Administration (FDA) audited the company, 71% of its studies were invalidated, and thousands were found to be fraudulent or grossly inadequate.

What started as serious concerns about poor quality research expanded into a criminal investigation, and in 1983 three men from IBT were convicted for fabricating key safety tests to gain government approvals. The fraud brought into question 15% of the pesticides approved for use, besides many pharmaceuticals and industrial chemicals.


IBT clients included Monsanto, Dow, and DuPont.

America's response to this fraud was to devise 'Good Laboratory Practice' (GLP). This quality assurance system provides a legal framework which specifies, for example, standard requirements for equipment and facility maintenance, experimental conditions, documentation of all procedures and data, archiving of all findings and materials, monitoring of personnel, and external auditing of test facilities.

Good Laboratory Practice was introduced into America in 1978 and adopted by the Organisation for Economic Co-operation and Development (OECD) in 1992 making it a world-wide standard. It was formally adopted by the EU in a 2004 Directive.

Problem sorted. 

Or, is it?

A question of what's natural

December 2021

GM proponents have been working hard to sow confusion about just how un-natural their intrusions into the genome and its connected molecular machinery actually are [see GENE-EDITED FARMING: RESCUE OR LAST STRAW? - December 2021].

Did you know that passing GM off as 'natural' has been a standard tactic used by jittery biotechnologists to distract a wary public since the dawn of GM?

Did you know that something which is patented can't, by legal definition, be described as 'natural'?

For a very informative discussion by a varied and knowledgeable panel, check out 

Gene-edited farming - rescue or last straw?

December 2021


Modern 'conventional' farming: too big, too uniform, too much fancy technology, too hype-ridden, and unsustainable.

Paving the way for the acceptance of Westminster's consultation on the regulation of genetic technologies, an opinion piece, written by a top UK crop-pest scientist, was published in the Guardian newspaper. Its headline was:

"Science can rescue farming. Relaxing gene editing rules should be the start"


The villains that farming needs to be rescued from are "new (climate-change driven) plant diseases moving rapidly around the world", and some old plant diseases (such as the blight which caused the Irish potato famine in the 1840s) which still plague us, and the skill and patience required for the long process of conventional plant breeding.

The heroes which will rescue farming are super-fast, precise, trait-specific new crops courtesy of gene editing.

The article also acknowledged that, before farming can be rescued by gene-editing, gene editing will have to be rescued from negative consumer opinion.

Take a step back and look at why our agriculture is being caught so far on the back foot that it needs rescuing.

In old-style 'conventional' plant breeding (a.k.a. 'domestication'), seed is saved, exchanged locally, and possibly selected for planting the following year. The plants evolve* alongside the farmers and everything else which shares their mutual environment. Farmers are producers with key skills in food production, while their naturally genetically-diversified crops evolve into new genetically-diversified crops.

* Note Evolution is an ongoing, ecosystem-wide shifting to new states of equilibrium as all organisms interact with each other and with their non-living environment. "Like all organisms, humans alter the environments around them in ways which have evolutionary consequences" (Mueller and Flachs)

Seventy years of the inappropriately named 'green' revolution have given us new-style 'conventional' (a.k.a. 'traditional') intensively-bred crops which are mainly inbred-hybrids. Such crops have uniform genetics and often include desired traits induced by humans using random mutagenesis (absent safety testing). They are developed off-farm with a prime focus on high yield to supply a globalised market. Key to growing such crops are chemical inputs (fertilisers and pesticides), the cash to buy the inputs and new seed every year, water, and the machines to enable uniform planting, multiple chemical applications, and harvesting on a vast scale. Add to these, government subsidies and an elaborate market infrastructure. Farmers growing them have become consumers of whatever seed, chemicals and machines their suppliers want to flog them.

The green revolution's monocultures and transportation of seeds around the world are big players in the global spread of plant diseases (the ones gene-editing will 'rescue' farming from), and climate change.

The focus on yield, uniformity and scale has long side-lined the nutritional value, taste and sustainability of the crop, and the needs and knowledge of the local people, and evolution. While the on-farm environment keeps changing, just like it always has, industry-supplied inbred-hybrid seed has no capacity for evolution.

The latest shift in agriculture is to crops which have been genetically modified (GM) or gene edited (also GM). These have desired specific traits engineered into them in the laboratory. In a desperate attempt to normalise these GM creations, genetic modification has been absurdly described as "a continuation of the ancient process of (crop) domestication" by which humans "have been manipulating their crops for millennia". Gene-editing takes the public sedation exercise a stage further: it "could happen in Nature" and “allows us to give Mother Nature a helping hand to accelerate the process of evolution". Since all GM traits are bred into existing crops varieties with uniform genetic backgrounds, they are quite clearly nothing to do with old-conventional, evolving, plant breeding and everything to do with new-conventional, non-evolving, green revolution crop production.

Consumers have every reason to be just as uncomfortable with gene editing as they were with genetic modification.

For one thing, there's the science (which isn't difficult to find or to grasp):

  • Apart from the question of functional disturbances in the genome caused by the intended DNA change, there's a mounting body of evidence that the gene editing process itself induces damage elsewhere in the genome [1,2,3].
  • The latest alarming discovery is the possibility that CRISPR gene editing can cause the chromosome to shatter and re-assemble haphazardly, with who-know-what effects on the GM organism.
  • Crop scientists check the success of their genetic engineering by looking for the desired edit at the 'precise location': random wreckage elsewhere remains invisible.

For another thing, as some concerned New Zealand scientists pointed out "the risk of harm from gene technology accumulates over time and scale of production". If Big Biotech gets its way on the scale of gene-tech crops grown all over the world, it's just a matter of time before the risk of harm becomes actual harm.

Then, there's the desperate and unconvincing propaganda such as that described above. As the concerned scientists in New Zealand pointed out, "the risks from technology don't disappear by calling it natural" (and, an edited gene doesn't become natural by calling it evolution).

Suggestions in the crop-pest scientist's article for tackling the public confidence deficit in gene editing include the need for transparency and a 'national debate'. That same month, a letter published in Nature Biotechnology advanced principles for 'Responsible governance of gene editing in agriculture and the environment' which included 'robust, inclusive societal engagement'. Note that no one's suggesting any need for safety testing to reassure the public. What all that transparency, debate and engagement sounds like is a smokescreen for 'educating' the public to want this new-fangled GM food, just like in the 1990s when the first old-style GM crops emerged from the field.

Relaxing gene editing rules' as suggested by the top UK crop scientist translates into a means to avoid safety testing. Indeed, the outcome of the 'consultation' is that UK regulators will now permit field trials of gene-edited crops without risk assessment, and new legislation to exclude gene-edited organisms from the definition of a GMO is now on Westminster's agenda.


OUR COMMENT

The hype surrounding all things GM hasn't changed in quarter of a century. Don't let yourself be 'educated' to think that gene-edited foods will ever be anything but a quick, commercially-lucrative patch shoring up an over-sized unsustainable system with multiple opportunities for harm to health.

The top UK crop scientist acknowledged that "Organic farming has provided us with creative and powerful alternatives for how we grow food" and hints that combining crop 'improvement' using gene-editing with organic methods could be a solution for sustainable agriculture. Obviously giving Mother Nature a helping hand ... and giving the biotech industry an even bigger helping hand while compromising our future organic food supply. Organic farming doesn't need rescued, but it will if genetic engineers get their hands on it.

Ask your MP to take action. Rather than rush simplistic gene edited 'improved' crops to market, the UK government must promote small-scale, diversified, climate-friendly, unadulterated organic, regenerative, and agro-ecological methods that work with nature and put farmers back in the driving seat. In that way, farming might actually rescue itself along with our health, our food supply and our future.

In Scotland, our Environment Minister tells us: 
"Scotland's policy towards GMOs has not changed, and we have no plans for a similar review. As for gene editing, we are disappointed DEFRA would choose to move unilaterally on this. The Scottish Government is committed to keeping aligned with the EU, and we are monitoring the EU's position closely". 
Now is a good time to tell your MSP that you don't trust the new gene technology trajectory of English agriculture and that you fully support Scotland's no GM and no gene editing policy.


Background

[1] THE PRECISION PROBLEM IN GENOME EDITING - August 2021

[2] CRISPR'S EPIGENETIC SCARS - August 2021

[3] CRISPR CATASTROPHE IN THE MAKING - August 2021

SOURCES:

·         DEFRA Consultation outcome, Genetic technologies regulation: government response, updated 29.09.21

·         Nick Talbot, Science can rescue farming. Relaxing gene editing rules should be the start, Guardian 19.09.21

·         Natalie G. Mueller and Andrew Flachs, September 2021, Domestication, crop breeding, and genetic modification are fundamentally different processes: implications for seed sovereignty and agrobiodiversity, Agriculture and Human Values

·         Barbara Van Dyck, The Stories We Trust: Regulating Genome edited Organisms, Agroecology Now! 23.07.21

·         British farmers 'could lead the way' on gene editing after Brexit, Farming UK 4.12.18

·         Jack Heinemann and others, Calling the latest gene technologies 'natural' is a semantic distraction - they must still be regulated, The Conversation, 22.09.21

·         Doria R. Gordon, et al., September 2021, Responsible governance of gene editing in agriculture and the environment, Nature Biotechnology Correspondence

·         Mitchell L. Leibowitz, et al., 2020, Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing, Preprint (subsequently published in Nature Biotechnology)

·         Chromothripsis: Bad news for gene editing, GM Watch, 22.09.21

Photo Creative Commons

How much don't we know about our food?

November 2021

Pity the poor plants. If you find something trying to eat you, you can run away, hide, bite back, kick, claw, or twist your way out, or avoid being in the wrong place at the wrong time to start with. Plants, held fast by the earth, can't evade or fight off predators: and there are lots of animals out there wanting to eat them.

One self-defence trick plants do have is a huge arsenal of chemicals with which to make themselves taste bad, look bad, indigestible, or poisonous.

Just how huge this arsenal might be can be judged by the composition of the humble iceberg lettuce. Mainly water and a little green colouring you might think? The US Department of Agriculture (USDA) recognises eleven constituents in an iceberg lettuce: detailed analyses have identified more than 4,000.

For those of us shoe-horned into thinking of food in terms of sugar, protein and fat with a few vitamins and minerals thrown in, this one real-life figure of 4,000-plus in a lettuce tells us just how dumbed down the information about our food is.

Doing the maths of bacterial burgers

November 2021

Do the sums of farm-free food fermented in the desert as the saviour of our over-heating planet really add up? [1].

The big why of fake food

November 2021


 

If you've just been reading about the plan to save the world by feeding people very strange burgers grown in vats on even stranger buns so that all the land we've destroyed with agriculture can be left to re-wild [1], you may well be asking yourself some 'why' questions.

Why would we consider junking the entire historic basis of human provisioning?

Why, when we're already suffering unprecedented chronic disease from our novel, over-processed, corporate-led diet, would we head off down a path which takes all these aspects to new extremes?

Why, when millions go hungry due to poverty, bad cultural influences and bad politics, are we concentrating on technofixes to our food chain?

Why, when there are more farmers in the world than in any other single job, would we scrap farming?

Cancer burgers in bacterial buns

November 2021

We're in a mess.

Our climate's crumbling and our ecosystem's in collapse.

Human 'progress' has become a one-way street, in which we're leaving a trail of devastation behind us and facing ever-more bleak views ahead.

In fact, we appear to be digging our own grave, and don't seem to know how to stop.

Avoiding evidence about cancer (linked to Glyphosate of course)

October 2021

Because humans can't be subjected to experimentation, regulators assessing the safety of a chemical have to weigh whatever other, imperfect, evidence they have at their disposal. Safety assessment is particularly challenging when dealing with a possible carcinogen, such as glyphosate herbicide [1]. It's even trickier, it seems, when the chemical is, like glyphosate, a major money-spinner produced by the powerful biotech industry for use on its commodity GM crops [2].

There are two important types of evidence available to regulators: laboratory experiments using animal models, and epidemiological studies. Neither can yield definitive conclusions, and their limitations are particularly evident in investigations of suspected carcinogens.

The shortcomings of animal models stem from the biology of cancers.

2,4-D on the menu too

October 2021

If you've just been reading about the two latest GM-crop-linked, cancer-causing herbicides to add to the glyphosate formulations already in use globally [1,2,3,4], don't relax, here's another one to worry about.

Last year, China approved Corteva's* 'Enlist' GM soya for importation. This secured a place for Enlist crops, plus the herbicide 2,4-D they're designed to be sprayed with, in US fields. It was described by GM seed suppliers, MS Technologies, as "great news for US soybean growers".

*Corteva Agriscience is a division of DowDupont

A former research professor who now works as a consultant for environmental groups said "2,4-D could by-pass glyphosate as the most widely used pesticide within a couple of years".

2,4-D and its sister chemical, 2,4,5-T, were two of several substances developed by Britain and America as herbicidal weapons during World War II. These two were formulated for use in equal quantities and were later packed in colour-coded containers to become known as 'Agent Orange'.

Isoxaflutole - The Next Herbicide Headache?

October 2021

In the 1990s, agrichemical giant, Bayer, was developing its own herbicide/GM-crop package to compete with Monsanto's hugely successful glyphosate and 'Roundup Ready' GM soya. However, as part of the Bayer-Monsanto merger deal, the company was required to off-load this product. The outcome, approved for the market in 2020, was isoxaflutole-resistant GM soya now produced by its new owner, BASF.

Isoxaflutole is a newcomer in the world of herbicides and is recognised as a probable human carcinogen because it induces liver and thyroid tumours in rodents. This herbicide is potentially toxic to the liver, blood and eyes, and may have negative developmental effects. It's pretty good at drifting, and is persistent and mobile in the environment, possibly accumulating in ground water.

All this may sound like a good reason not to approve isoxaflutole nor the GM crops designed to escalate its use. 

Dicamba - Worse Than Glyphosate

October 2021 


 

After all the whitewashing of glyphosate herbicide revealed when its manufacturer, Monsanto, was taken to court by users who now have cancer [1], it should come as no surprise that dicamba herbicide [2] looks like being a re-run of the same story.

Glyphogoats

September 2021


As glyphosate's reputation disappears down the drain [1,2], and European countries progressively tighten regulations on the use of this herbicide, various new and old alternative approaches have been proposed to deal with weeds. These have included hot foam, blow-torching, hot water, old-fashioned hoeing and hand-weeding, or even simply tolerating weeds if their presence isn't causing a problem except to the tidy-minded.

Another way to get rid of weeds is to eat them, or rather get something that likes the taste of weeds to eat them for you. 

The Glyphosate Cancer Lag Phase is over

September 2021


Cancer is, without doubt, one of the most devastating of modern diseases. Treatment is limited and unpleasant, and prevention is difficult because of the biology of cancers.

Cells become cancerous when physical and/or chemical stressors disturb gene function to the point where the normal protective cell repair and rebalancing mechanisms are overwhelmed. The prevention problem arises because there isn't one single cause, but rather a whole raft of contributing factors which combine in complex ways to trigger the disease of the cell. For example, exposure to stressors at a low intensity for a long time may cause cancer just as surely as a high dose of the same stressor for a brief period. A variable lag phase, ranging from months to decades makes identifying the cause of any cancer particularly tough.

All these complications are bad news for people whose food, water, air and environment are laced with potentially carcinogenic agrichemicals. They're even worse news for the people whose job it is to spray the world with these chemicals. However, they're excellent news for agrichemical and biotech companies who don't want any evidence that their top moneyspinners may be guilty of causing cancer.

Glyphosate is damaging our children

September 2021

 


Glyphosate-based herbicides have become ubiquitous in our food chain and in our environment. Their presence has been boosted, especially, by GM glyphosate-tolerant commodity crops such as soya, maize, sugar-beet, cotton, and oil-seed rape.

How much damage are these herbicides doing to our children? Even before they've been born? And even threatening their very existence?

Epigenetic mayhem courtesy of glyphosate

September 2021


 

Epigenetics are defined as 'molecular factors and processes around DNA that regulate genome activity, independent of DNA sequence, and are. stable (during cell division)'. They regulate gene activity by turning specific genes on and off.

So far, at least five epigenetic processes have been identified, including chemical groups which attach to DNA or to the RNA expressed by the DNA, besides structural effects on the chromosome. Such processes are reversible, but can also be passed down through many generations.

The epigenome (totality of epigenetics) plays a key role in health and disease. Individuals (animals or plants) are the outcome of the integrated actions of all the epigenetic processes they have inherited or acquired during their life-time.

Known causes of epigenetic changes which are passed on to the next generation in humans include environmental toxins, nutrition, stress and smoking.


Scientists in the Center for Reproductive Biology in Washington State University have carried out an experiment which suggests that glyphosate herbicide could be a significant contributor to the current escalating incidence of chronic disease. If they're right, it means that we're still near the beginning of that wave of disease which will continue to surge for the next two generations and beyond, unless we do something about it.

Caution! GM ahead

September 2021


Sedated by the GM food labelling and risk assessment requirements of the EU, many British people have been lulled into thinking GM has become a bit of a non-issue. However, just before Covid 19 obliterated all other news, many media outlets were picking up on the real possibility that, post-Brexit, "Supermarkets could be stocked with genetically modified food under future UK-US trade deal" (The Sun). Indeed, some were warning of the risk of a race to the bottom [1] and asking what happened to Westminster's pledge to take back control of our markets [2].

What started it was that, while "Boris Johnson has repeatedly claimed that negative impacts of Brexit will pale in comparison to the benefits" (Lib Dems quoted in PoliticsHome), the government's own figures suggest the 'benefits' could be as low as 0.02% of GDP. The UK Trade Policy Observatory at Sussex University commented "The numbers are very small. It just goes to show how tiny the gains are from a free trade agreement with the US compared to losing our present arrangements with the EU".

To avoid upsetting the public, the Government categorically ruled out involving the NHS in any trade negotiations, while allowing the health and safety issues surrounding US produce (which our Prime Minister has dismissed as "mumbo jumbo"), to be side-lined into the easily explained issues of chlorine-treated chicken and hormone-treated beef. On the subject of GM and food safety, however, the UK's negotiating stance has been over-generalised and elastic: "Any agreement will ensure high standards and protections for consumers and workers, and will not compromise on our high environmental protection, animal welfare and food standards." (quoted in The Sun)

This is not good news for British farmers who face the double-whammy of their home market being flooded with cheap (GM, and heavily subsidised) American produce just at the same time as their export markets to Europe have vanished.

The National Farmers' Union (NFU) for England and Wales, whose mission is to give farmers a voice, to protect their way of life, to campaign for a stable and sustainable future for British farmers, and to secure them the best deal, has been narrowly focusing on a ban on chlorine-treated chicken. At the same time, despite knowing its members' customers clearly rejected GM foods in the past and have no reason whatsoever to have changed their minds, the NFU is lobbying hard for gene editing. The organisation claims that this unproven GM technology will put the UK "in a world-leading position to showcase sustainable climate-friendly farming " (Blythman). Given the unpredictable disturbances in gene edited genomes increasingly being revealed by science [3,4,5,6], the NFU's wild optimism really doesn't sound like the best deal for farmers. This US-style, high-tech idealism puts the NFU at odds with its sister organisations in Scotland and Northern Ireland which have banned GM crops of all kinds.

As journalist Joanna Blythman warned pre-Brexit:

Laser-precise gene-edited accident

August 2021


 
Hypothesis -

  1. Supposition made as the basis for reasoning, without assumption of its truth, or as a starting-point for investigation 
  2. Groundless assumption
(Oxford English Dictionary)

A brief perusal of the website of biotech company, Cibus, will give a you a good idea of what it sells.

Cibus uses its own "unique and proprietary precision gene-editing technologies" to "enable the direct creation of desired traits without integration of foreign material for nature identical non-GMO crops".

Note that "GMO" is not a good selling point. Cibus is plugging the make-believe that gene-edited GMOs are somehow not GMOs and therefore somehow more acceptable to consumers.


The bases of Cibus gene-editing technologies are its 'Rapid Trait Development Systems' (RTDSTM) which involve culturing 'naked' parent plant cells stripped of their protective walls. In this highly unnatural form the cells are unstable and prone to mutation. They're also vulnerable to chemical attack, and this can be used to enable the uptake of a simple synthesized nucleotide* gene editor.

*DNA is a nucleic acid formed from a chain of nucleotide molecules.


Cibus' first commercial RTDS product is 'SU canola', a gene-edited canola tolerant to sulfonylurea herbicide. The novel canola has a single nucleotide change in a gene for an essential enzyme which in its native form is inactivated by the herbicide.

Actually, this first gene-edited crop, Cibus SU canola, is just another version of what all the biotech companies have been churning out for decades: a lucrative package of a GM herbicide-tolerant commodity crop with it's own herbicide.


In 2016, the Canadian regulators who approved Cibus' SU canola for food use noted that it was created using RTDS and a nucleotide-directed mutagenic technique, and that the precision of the edit in the crop had been confirmed by DNA analysis. They also noted that, notwithstanding the use of a precision gene-editing tool and the confirmation of that precision, Cibus "hypothesized that the single nucleotide mutation was the result of a spontaneous somaclonal (culture induced) variation that occurred during the tissue culture process, and not due to the specific oligonucleotide* used in the RTDS protocol".

*An olignucleotide is a short chain of nucleotides


No basis for the latter supposition was given, and the regulators seem unconcerned that Cibus appears not to have mastered its own "laser precise" gene-editing tool which it claimed to be the very foundation of its business model.

Comment. Indeed, it seems somewhat lax of regulators to approve any novel crop on the basis of a 'supposition' or 'groundless assumption' about how it was created in the first place.


Four years later, the hypothesis became an established fact slipped, without fanfare, into select media outlets. Euroseeds, 'the voice of the European seed sector', reported that the SU canola was "in fact developed from spontaneous somaclonal variation".

French campaign group Inf'OGM dug a bit deeper and found Cibus explanation: "the herbicide selection step identified multiple herbicide tolerant plants. These plants came from cells in Petri dishes where an oligonucleotide was added and also from control cell samples in Petri dishes where no oligonucleotide was added ... We were pleased to find that some of the plants had the specific mutation the oligonucleotide was designed to induce, but the majority of the tolerant plants had a variety of different mutations that had arisen spontaneously during the cell culture process." Cibus concludes by saying that it "selected one of the spontaneous mutations ... this became our first SU Canola line".

Cibus seems to be saying its laser-precise gene editor worked in a few plants but that plenty of suitably mutated, non-edited plants arose spontaneously. However, the commercialised SU canola was confirmed by DNA analysis to have the laser-precise edit intended. Since single genes consist of millions of nucleotides within a genome of billions, the chance of one single exact planned laser-precise change in a single nucleotide arising spontaneously in a few cells in a dish is, as Dr John Fagan pointed out, "vanishingly small". He added "it is highly preposterous that a company that has invested tens of millions in developing a particular method of gene editing would turn around and claim that its first commercial product made using this gene editing method was not actually the result of that method but happened accidentally via random mutagenesis."

COMMENT


There would seem to be a vanishingly small chance that Cibus is oblivious to the points made by Dr. Fagan. So, what's going on?

Was Cibus smart enough to give itself a get-out clause for RTDS in case gene-edited GMOs became the liability transgenic GMOs have become? After all, if the first gene-edited crop 'success' story could so easily become a cell culture miracle, so could all the rest.

And, GM proponents keep insisting that gene edited plants are 'nature identical', merely an escalation of what happens in nature, and indistinguishable from what happens in nature, s
o no one's ever going to be able to prove industry is indulging in wishful thinking. Or are they?


GM-concern groups have pointed out that just before Cibus concluded its four-year deliberation on whether SU canola might have arisen by spontaneous mutation, a study was published inconveniently disproving the claim that gene-edited plants couldn't be identified and therefore couldn't be regulated. The study described analytical methods which "may be applicable to virtually any genome-edited organism", providing that basic information about the DNA edit as supplied to regulators is available. Their methods used widely-available scientific expertise and common equipment already in routine use in laboratories.

To trial their method, the scientists used Cibus SU canola because it has some particularly challenging features.

Challenging features for the analysis of Cibus SU canola include, for example:

  1. The edit involved a single-nucleotide edit, the smallest change possible.
  2. The gene altered isn't unique in the organism, it's just one member of a set of similar genes.
  3. The SU crop Cibus finally commercialised is a hybrid between the RDTS-generated plants and a chemically-mutated version with the same single nucleotide change in a different gene in this set.


With these kinds of challenges, if the techniques work for SU canola, they'll work for any other gene-edited crop.


What better moment to find out that all those annoying tests and inconvenient regulations looming for gene edited crops such as SU canola can be dispensed with because the edit has been declared a natural mutation? Indeed, Euroseeds took pains to announce that the published detection method had merely detected a natural mutation and so was making "much ado about nothing".


OUR COMMENT


There's another explanation which is much, much more likely than that vanishingly unlikely spontaneously laser-precise accident.

During the long procedure of cell culture, molecular treatments and plant regeneration, there's significant scope for operator errors: did the culture plates or the plants get mixed up? was the wrong reagent added to a cell culture? did the labels get mixed up?

Cibus haven't come clean on how it managed to eliminate all these possibilities.

On the other hand, if Cibus is right and its SU canola is a result of spontaneous mutation, there's an interesting implication. Despite all the purposefully gene-edited plants it created, it was one which hadn't been subject to a humanly-contrived nucleotide change which formed the best stock for commercialisation. This would suggest Cibus' miracle plant which had changed by itself was much more robust than the GM ones ... not a great sales pitch for their designed, laser-precise, gene-edited crops.

Bear all this in mind next time you hear how wonderful gene-edited crops promise to be (especially from our own Department of Environment Food and Rural Affairs [1])

Background

[1] THE PRECISION PROBLEM IN GENOME EDITING - June 2021


SOURCES:

  • www.cibus.com

  • Novel Food Information - Cubus Canola Event 5715 (Imidazolinone and Sulfonylurea Herbicide Tolerant), Novel Food Information, Government of Canada, 27.05.16

  • Claire Robinson, Company claims first commercial gene-edited crop wasn't gene-edited after all, GM Watch 21.09.21

  • Cibus's canola. The mysterious origin of the mutation, GM Watch 29.09.20

  • Greg Gocal, Non-Transgenic Trait Development in Crop Plants Using Oligo-Directed Mutagenesis Cibus' Rapid Trait Development System, Cibus 2014

  • Much ado about nothing, really! www.euroseeds.eu, 8.09.20

  • First open source detection test for a gene-edited GM crop, GM Watch, 7.09.21

  • Pradheep Chhalliyil, et al., 2020, Real-Time Quantitative PCR Method Specific for Detection and Quantification of the First Commercialized Genome-Edited Plant, Foods 9

    Photo Creative Commons

CRISPR catastrophe in the making?

August 2021


 
"CRISPR editing wreaks chromosomal mayhem in human embryos"

(Nature 2.07.20)

"If human embryo editing ... were space flight, the new data are the equivalent of having the rocket explode at the launch pad before take-off"

(University of California genetic engineer, Nature 2.07.20)

"There's no sugar-coating this. This is a restraining order for all genome editors to stay the living daylights away from embryo editing"
(University of California genetic engineer, The Scientist 26.06.20)
More than 10,000 single-gene inherited human disorders have been identified, and genetic engineers have long held a dream of sorting out our defects. Gene editing techniques, such as CRISPR [1], seem like a heaven-sent opportunity to tweak these dysfunctional genes back to normality.

CRISPR's epigenetic scars

August 2021

 epi- (prefix) = in addition 

gene = functional unit of DNA expressing a protein

-ome (suffix) = all constituents considered collectively

genome = total complement of functional DNA

epigenome = total complement of additional regulatory biochemicals and biochemical

processes linked to the genome


At least five epigenetic effects have so far been identified, including substances which attach to the DNA or to the RNA expressed by the DNA, and structural changes in the chromosome.

Epigenetic factors are used by mature cells to enable or disable genes as needed to achieve their specialised function.

Environmental toxins, poor nutrition and other stresses can inflict epigenetic changes linked to disease, and if they affect the reproductive cells, the unhealthy epigenome can be inherited by future generations.


As if we didn't have enough concerns about damage to the health of the genome caused by artificial changes in its DNA, science has uncovered another insidious problem in GM organisms.

CRISPR is a favourite DNA-editing tool which can be used to insert genes in precise locations in the genome [1]. However, an experiment on mice found that the desired, precise genetic transformation was accompanied by undesirable changes in the epigenome. These changes were passed down through at least 10 generations.

The epigenetic factor investigated was the attachment of 'methyl' molecules to specific sequences of DNA (a reaction which usually inactivates the gene).

The precision problem in genome editing

August 2021

In 2018, the European Court of Justice gave its opinion on EU law with regard to gene editing. It concluded that techniques which use lab-made nucleic acids (such as DNA or the related RNA) to alter genetic material in a way that does not occur naturally are GM and are, therefore, subject to GMO regulation [1].

We're back!

August 2021

Dear readers,

Welcome back to GM-Free Scotland!

While GM-Free Scotland has been in lockdown, the biotech industry has been busy convincing our food regulators that gene-editing is somehow so safe and dependable that it doesn't need regulation, testing or labelling.

Biotech industry rhetoric, obediently repeated by government (both Westminster and Holyrood), is that gene editing is "like nature", simply "speeding up something which would happen with breeding eventually", "precise" and involving "no foreign genes". We are told we must not "shut our eyes to scientific advancement" and that we must "be led by the science on gene editing technologies". But this science-led advancement doesn't seem to extend to actually using science to make sure these new GMOs are safe and healthy for the current generation, for future generations, for our food crops and for our environment.

If you're not sure what the problem is with gene-edited food, make sure you catch the next few GMFreeScotland articles on what science is telling us about them.

Stay safe!

Quotes are from:

Farmers to be at the helm of future policy direction in a new Holyrood by Claire Taylor, the Scottish Farmer, 29.4.21

Why new genetic techniques need to be stringently regulated, Third World Network Biosafety Information Service, 4.04.21