CC photo of crop spraying in Norfolk - via timparkinson on Flickr |
Scientists at the Indian Institute of Toxicology in Lucknow,
have previously reported that glyphosate has tumour-promoting potential in a
mouse skin model. Further investigation,
using cultured human skin cells as a 'normal' model, have identified the
underlying mechanism. It seems
glyphosate interferes with calcium-ion dependent processes inside the cell.
Calcium plays a pivotal part of the regulation of many key
cellular activities including cell development, proliferation, secretion, gene
activation, and natural cell death.
While glyphosate as a pure chemical is known to bind to
metal ions, any effects inside the cell, where calcium is bound to proteins and
may be associated with membranes, are too complex to predict. However, the Indian team's experiments
demonstrated that the herbicide does indeed disrupt calcium function within the
cell.
They identified a glyphosate-induced calcium depletion in their cells, along with suppression of vital calcium-dependent enzymes. Knock-on effects included a down-regulation of the processes leading to natural cell death, and the generation of toxins (reactive oxygen species) by the cells. These toxins are known to cause cell dysfunction and malignant transformation.
They identified a glyphosate-induced calcium depletion in their cells, along with suppression of vital calcium-dependent enzymes. Knock-on effects included a down-regulation of the processes leading to natural cell death, and the generation of toxins (reactive oxygen species) by the cells. These toxins are known to cause cell dysfunction and malignant transformation.
Their studies on skin cells exposed to glyphosate showed
clear dose- and time-dependent effects.
At low levels, the herbicide induced cell proliferation which, in
conjunction with a failure of normal cell death, could link to tumour
formation, and set the scene for cancer.
At higher levels, glyphosate is toxic and the exposed cells decline.
In June 2013, Friendsof the Earth and GM Freeze published the results of Europe-wide tests for
glyphosate levels in humans. Urine
samples were obtained from 182 volunteers in 18 countries across Europe,
including 10 from the UK. All the
volunteers lived in cities and none had handled nor used glyphosate products in
the run up the testing. On average 44
per cent of samples contained traces of glyphosate (70 per cent in the UK).
Glyphosate is used on many crops before harvest and
accumulates in many GM crops with inserted glyphosate-tolerance genes. It can reach ground-water by a number of
routes. Despite this, its presence food,
feed and water is rarely monitored.
OUR COMMENT
A substance to which our bodies may be continually exposed,
and which can disrupt cell function at such a fundamental level as its calcium
balance, could be very damaging indeed.
Glyphosate toxicity studies have always focused on acute
toxic effects which only occur at higher doses and have enabled the herbicide
to be marketed with a 'safe-as-salt' image [2].
Clearly, lower, non-toxic, 'safe' doses have a real carcinogenic potential.
The possibility of a direct link between glyphosate exposure and increasing
cancer incidence [3], promoted by escalating levels in the GM food chain seems
ever more likely.
Just another reason (if you needed one) not to eat GM
food. It also might be a reason to start
pressuring the Department of the Environment and Rural Affairs to disallow the
practice of spraying glyphosate on (non-GM) crops as a harvesting aid.
Background:
[2] GLYHPOSATE - SAFE AS SALT? - (Document link) GMFS Archive, February
2009
[3] US PUBLIC HEALTH TRENDS AFTER GM - October 2013
SOURCES:
Jasmine George and Yogeshwer
Shukla, 2013, Emptying of Intracellular Calcium Pool and Oxidative Stress
Imbalance Are Associated with the Glyphosate-induced Proliferation in
Human Skin keratinocytes HaCaT Cells,
ISRN DermatologyJasmine George et al., 2010, Studies on glyhphosate-induced carcinogenicity in mouse skin: A proteomic approach, Journal of Proteomics 73:5
GovernmentUrged to Act After Weedkiller Traces Found in Britons, GM Freeze and Friends of the Earth Press Release, 13.06.13
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