July 2013
Wheat. CC photo by Wheat Initiative on Flickr |
The latest development in genetic modification isn't inserting
genes, it's inserting DNA to
induce RNA interference, in particular double-stranded RNA, 'dsRNA' .
As
described in RNA-MODIFIED FOOD - July 2013, the
technique has a huge potential for side-effects. Reading this, “How
can anyone still think it's safe to apply (RNA interference) in
genetic modification?” (Institute of Science in Society).
Yet, dsRNA
technology is in several pipe-line GM crops, one of which is a major
global staple food, wheat.
This GM wheat is
being developed in Australia* to have altered starch composition.
The intention seems to be to create wheat grain with starch which is less
digestible than normal. The hope is this will make it 'healthier' by improving
large bowel health and cholesterol levels, and by reducing blood
sugar in the same way as oats, rye, lentils and peas do.
A database
investigation, however, has revealed a number of side-effects which
will not be so healthy.
The novel dsRNA
sequence matches with five stretches of DNA in one wheat gene alone.
There's a clear potential for the dsRNA to combine with any or all of
these matches and disable the gene.
Such bioinfomatic
investigations are far from comprehensive in their ability to predict
off-target side effects: there may be many more unanticipated changes
in the wheat.
Then, the story gets
worse.
The
dsRNA in this GM wheat also matches DNA stretches in some human
genes. Our genes could be
silenced by the novel dsRNA in our food. In fact, disruption to
human physiology by the dsRNA in this wheat has the potential to
permanently silence hundreds of human genes.
At least one
specific risk to humans has been identified: children exposed to the
starch altered GM wheat from the maternal diet could be born with a
key liver-function gene silenced. Without the enzyme this gene
generates, the children will be unable to store sugar normally: the
unusable forms of sugar will build up in their liver and heart
tissues to the point where these vital organs fail. Any one with
this deficiency will die by about five years of age.
In addition to
direct effects on genes, dsRNA interference with other natural and
vital RNA-interference systems is possible.
Bakers and other
wheat handlers will breathe in large doses of the GM wheat as
air-born particles, and the skin of their hands may be in extensive
contact with it.
Or,
as molecular geneticist, Dr. Michael Antoniou, commented, if the GM
wheat is consumed, gene function disturbances are virtually
inevitable, with currently
unknown health consequences.
A similar GM barley with altered grain
starch is also in the pipeline.
OUR COMMENT
Wheat intolerance is an ever-rising
modern scourge. What might unfold if this dsRNA-modified GMO ever
gets into our food chain doesn't bear thinking about.
Start complaining to our food
regulators NOW: make sure that dsRNA never gets a chance to cause the
havoc it so clearly can.
*The developer of this GM wheat is the Commonwealth Scientific and Industrial Research Organisation (CSIRO), which is ostensibly publicly funded, but gets about 30% of its funding from industry, and has plans to increase it. One former chief executive commented “Working with the transnationals makes a lot of sense, in the context of market access”.
*The developer of this GM wheat is the Commonwealth Scientific and Industrial Research Organisation (CSIRO), which is ostensibly publicly funded, but gets about 30% of its funding from industry, and has plans to increase it. One former chief executive commented “Working with the transnationals makes a lot of sense, in the context of market access”.
SOURCES:
- Judy A. Carman, Expert Scientific Opinion on SCIRO GM Wheat Varieties, September 2012
- Jack A. Heinemann, Evaluation of risks from creation of novel RNA molecules in genetically engineered wheat plants and recommendations for risk assessment, Expert opinion, 28.08.12
- Scientists warn of GM wheat health dangers, GM-Free Cymru, 12.09.12
- CSIRO profile, www.powerbase.info/index.php/CSIRO
- Dr. Mae-Wan Ho, RNA Interference”Complex and Flexible, Institute of Science in Society Report, 22.05.13
- New kinds of GM plants and pesticides not being assessed for safety, Centre for Integrated Research in Biosafety Press release, 21.03.13
- Dr Mae-Wan Ho, New GM Nightmares with RNA, Institute of Science in Society Report, 29.04.13
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