Evolutionary breeding, just like weeds

September 2022

Despite all the toxins, genetic devices, and shear physical destruction we throw at them, pests of all kinds continue to thrive in our fields. As climate change imposes all manner of unusual stresses on the environment, farmers and their crops struggle, while pests go from strength to strength.

It's not too difficult to see why. 

GM - an unsustainable, pro-rich technology

May 2022

Indian farmers first embraced GM cotton in 2002. 'Bollgard' cotton with its very own 'Bt' insecticide-generating gene, was heralded as a sustainable, pro-poor technology which would provide substantial benefits to smallholders. It promised reduced pest-damage, reduced chemical treatments, and increased yields.

In a country which contributes a quarter of global cotton, and has seven million smallholder farmers, Bollgard was a silver bullet to combat a key pest.

Within five years, however, the silver bullet was getting tarnished and the pests on cotton were ignoring it. Enter Bollgard II with two varieties of Bt toxin generated at higher levels and combatting more pests.

Gene-edited farming - rescue or last straw?

December 2021

Modern 'conventional' farming: too big, too uniform, too much fancy technology, too hype-ridden, and unsustainable.

Paving the way for the acceptance of Westminster's consultation on the regulation of genetic technologies, an opinion piece, written by a top UK crop-pest scientist, was published in the Guardian newspaper. Its headline was:

"Science can rescue farming. Relaxing gene editing rules should be the start"

---

The villains that farming needs to be rescued from are "new (climate-change driven) plant diseases moving rapidly around the world", and some old plant diseases (such as the blight which caused the Irish potato famine in the 1840s) which still plague us, and the skill and patience required for the long process of conventional plant breeding.

The heroes which will rescue farming are super-fast, precise, trait-specific new crops courtesy of gene editing.

The article also acknowledged that, before farming can be rescued by gene-editing, gene editing will have to be rescued from negative consumer opinion.

Take a step back and look at why our agriculture is being caught so far on the back foot that it needs rescuing.

In old-style 'conventional' plant breeding (a.k.a. 'domestication'), seed is saved, exchanged locally, and possibly selected for planting the following year. The plants evolve* alongside the farmers and everything else which shares their mutual environment. Farmers are producers with key skills in food production, while their naturally genetically-diversified crops evolve into new genetically-diversified crops.

* Note Evolution is an ongoing, ecosystem-wide shifting to new states of equilibrium as all organisms interact with each other and with their non-living environment. "Like all organisms, humans alter the environments around them in ways which have evolutionary consequences" (Mueller and Flachs)

Seventy years of the inappropriately named 'green' revolution have given us new-style 'conventional' (a.k.a. 'traditional') intensively-bred crops which are mainly inbred-hybrids. Such crops have uniform genetics and often include desired traits induced by humans using random mutagenesis (absent safety testing). They are developed off-farm with a prime focus on high yield to supply a globalised market. Key to growing such crops are chemical inputs (fertilisers and pesticides), the cash to buy the inputs and new seed every year, water, and the machines to enable uniform planting, multiple chemical applications, and harvesting on a vast scale. Add to these, government subsidies and an elaborate market infrastructure. Farmers growing them have become consumers of whatever seed, chemicals and machines their suppliers want to flog them.

The green revolution's monocultures and transportation of seeds around the world are big players in the global spread of plant diseases (the ones gene-editing will 'rescue' farming from), and climate change.

The focus on yield, uniformity and scale has long side-lined the nutritional value, taste and sustainability of the crop, and the needs and knowledge of the local people, and evolution. While the on-farm environment keeps changing, just like it always has, industry-supplied inbred-hybrid seed has no capacity for evolution.

The latest shift in agriculture is to crops which have been genetically modified (GM) or gene edited (also GM). These have desired specific traits engineered into them in the laboratory. In a desperate attempt to normalise these GM creations, genetic modification has been absurdly described as "a continuation of the ancient process of (crop) domestication" by which humans "have been manipulating their crops for millennia". Gene-editing takes the public sedation exercise a stage further: it "could happen in Nature" and “allows us to give Mother Nature a helping hand to accelerate the process of evolution". Since all GM traits are bred into existing crops varieties with uniform genetic backgrounds, they are quite clearly nothing to do with old-conventional, evolving, plant breeding and everything to do with new-conventional, non-evolving, green revolution crop production.

Consumers have every reason to be just as uncomfortable with gene editing as they were with genetic modification.

For one thing, there's the science (which isn't difficult to find or to grasp):

• Apart from the question of functional disturbances in the genome caused by the intended DNA change, there's a mounting body of evidence that the gene editing process itself induces damage elsewhere in the genome [1,2,3].
• The latest alarming discovery is the possibility that CRISPR gene editing can cause the chromosome to shatter and re-assemble haphazardly, with who-know-what effects on the GM organism.
• Crop scientists check the success of their genetic engineering by looking for the desired edit at the 'precise location': random wreckage elsewhere remains invisible.

For another thing, as some concerned New Zealand scientists pointed out "the risk of harm from gene technology accumulates over time and scale of production". If Big Biotech gets its way on the scale of gene-tech crops grown all over the world, it's just a matter of time before the risk of harm becomes actual harm.

Then, there's the desperate and unconvincing propaganda such as that described above. As the concerned scientists in New Zealand pointed out, "the risks from technology don't disappear by calling it natural" (and, an edited gene doesn't become natural by calling it evolution).

Suggestions in the crop-pest scientist's article for tackling the public confidence deficit in gene editing include the need for transparency and a 'national debate'. That same month, a letter published in Nature Biotechnology advanced principles for 'Responsible governance of gene editing in agriculture and the environment' which included 'robust, inclusive societal engagement'. Note that no one's suggesting any need for safety testing to reassure the public. What all that transparency, debate and engagement sounds like is a smokescreen for 'educating' the public to want this new-fangled GM food, just like in the 1990s when the first old-style GM crops emerged from the field.

Relaxing gene editing rules' as suggested by the top UK crop scientist translates into a means to avoid safety testing. Indeed, the outcome of the 'consultation' is that UK regulators will now permit field trials of gene-edited crops without risk assessment, and new legislation to exclude gene-edited organisms from the definition of a GMO is now on Westminster's agenda.

OUR COMMENT

The hype surrounding all things GM hasn't changed in quarter of a century. Don't let yourself be 'educated' to think that gene-edited foods will ever be anything but a quick, commercially-lucrative patch shoring up an over-sized unsustainable system with multiple opportunities for harm to health.

The top UK crop scientist acknowledged that "Organic farming has provided us with creative and powerful alternatives for how we grow food" and hints that combining crop 'improvement' using gene-editing with organic methods could be a solution for sustainable agriculture. Obviously giving Mother Nature a helping hand ... and giving the biotech industry an even bigger helping hand while compromising our future organic food supply. Organic farming doesn't need rescued, but it will if genetic engineers get their hands on it.

Ask your MP to take action. Rather than rush simplistic gene edited 'improved' crops to market, the UK government must promote small-scale, diversified, climate-friendly, unadulterated organic, regenerative, and agro-ecological methods that work with nature and put farmers back in the driving seat. In that way, farming might actually rescue itself along with our health, our food supply and our future.

In Scotland, our Environment Minister tells us: 

"Scotland's policy towards GMOs has not changed, and we have no plans for a similar review. As for gene editing, we are disappointed DEFRA would choose to move unilaterally on this. The Scottish Government is committed to keeping aligned with the EU, and we are monitoring the EU's position closely". 

Now is a good time to tell your MSP that you don't trust the new gene technology trajectory of English agriculture and that you fully support Scotland's no GM and no gene editing policy.


Background

[1] THE PRECISION PROBLEM IN GENOME EDITING - August 2021

[2] CRISPR'S EPIGENETIC SCARS - August 2021

[3] CRISPR CATASTROPHE IN THE MAKING - August 2021

SOURCES:

·         DEFRA Consultation outcome, Genetic technologies regulation: government response, updated 29.09.21

·         Nick Talbot, Science can rescue farming. Relaxing gene editing rules should be the start, Guardian 19.09.21

·         Natalie G. Mueller and Andrew Flachs, September 2021, Domestication, crop breeding, and genetic modification are fundamentally different processes: implications for seed sovereignty and agrobiodiversity, Agriculture and Human Values

·         Barbara Van Dyck, The Stories We Trust: Regulating Genome edited Organisms, Agroecology Now! 23.07.21

·         British farmers 'could lead the way' on gene editing after Brexit, Farming UK 4.12.18

·         Jack Heinemann and others, Calling the latest gene technologies 'natural' is a semantic distraction - they must still be regulated, The Conversation, 22.09.21

·         Doria R. Gordon, et al., September 2021, Responsible governance of gene editing in agriculture and the environment, Nature Biotechnology Correspondence

·         Mitchell L. Leibowitz, et al., 2020, Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing, Preprint (subsequently published in Nature Biotechnology)

·         Chromothripsis: Bad news for gene editing, GM Watch, 22.09.21

Photo Creative Commons

A tale of microbes, your gut and disease

December 2019

Scientists who have escaped the distortions of the reductionist mindset, in which 'life' is a mixture of chemicals dictated by genes, are beginning to recognise that organisms have two genomes*: the 'primary' genome is inside cells and is responsible for cell structure and function; the 'secondary' genome may consist of more genes than the primary one and is contained in the wealth of microbes inside and outside the organism, effectively a dynamic interface between the environment and the individual.

*The genome is the total complement of DNA including genes and other gene-regulating sequences in the individual (US National Library of Medicine)

There's increasing awareness that the quality, proportions and diversity of microbe species in our gut is closely connected to health and disease. Disturbances in our digestive tract flora have been linked to numerous chronic diseases, for example, allergies, autoimmune disorders (such as type 1 diabetes), arthritis, obesity, cardiovascular problems, cancer, learning and memory impairment, anxiety, stress, depression, autism and dementia. Our gut bugs play a leading role in neutralising a huge range of environmental pollutants before they can harm us, and in keeping pathogens at bay.

Pesticides in the population

October 2019

In 2017, a study was published indicating yet another possible chronic health effect from eating glyphosate, the herbicide sprayed on, and accumulated by, most GM crops.

The biotech industry has tried to claim that the presence of glyphosate excreted in urine proves the weedkiller is safe because the body is able to clear it out. However, tests on cows (not possible on humans) have shown glyphosate is distributed evenly in their organs and urine, suggesting the herbicide is retained in the body.

The case for diversity

September 2019

The need for diversity in our food supply has been a hot topic lately [1, 2].

Green Revolution agriculture gave us monocultures of a tiny range of high-calorie crops.  The Gene Revolution of recent decades compounded this with GM versions of the same crops. Commercial GM plants are overwhelmingly designed to be used in conjunction with a single herbicide, and many generate a small range of very similar insecticides.

Paradoxically, the end-products of these staple crops have diversified.  The excuse for developing them may originally have been feeding the hungry, but large quantities of that 'food' are now diverted into biofuel-production, industrial chemicals and animal feed.

Those that do reach the human stomach are highly processed carbohydrates and chemicals (a.k.a. junk food, or food-like substances).  In the dietary desert we now inhabit, our animals' nutritional needs are better met than ours.

A tale of two villages in India

September 2019

Is it just a romantic, anti-science notion to ditch agrichemicals, GMOs, monocultures and patents?  Or, is it a necessity?

This is the story of how small-holders become trapped by addiction to pesticides, and how two villages in India got clean.

Super-simplified agri-systems support disease

August 2019

E.coli 0157 -

In 1996, an outbreak of E.coli 0157 bacterial disease in Scotland involved the largest recorded number of infected adults in whom the early digestive-tract symptoms progressed to life-threatening kidney disease. Twenty-eight of them died.

That same year, 7,966 individuals were diagnosed with E.coli 0157 infection in a single outbreak in Japan.

Because the guts of healthy cattle are a reservoir for E.coli 0157, the animals, their manure, and the land they've grazed, are potential sources of the infection. The bacteria can also make their way from fields into the water supply.

The Scottish E.coli 0157 outbreak was caused by contaminated raw meat stored next to cooked meat. The Japanese outbreak was caused by radish sprouts contaminated by infected water.

Organic foods have always been seen as an arch-enemy by biotech proponents. In a desperate attempt to trash organics, they've even been blamed for deadly infections of E.coli 0157 bacteria.

Insectageddon

April 2019

"... having taken every step science can offer to devitalise the soil and its food that supports him, (man) is now turning his attention to destroying the insect world upon which he is also dependent." ... "... if birds eat insects poisoned by (pesticides) this can kill them - a striking tribute to the intelligence of 'scientists', since birds are our best safeguard against pests." (Easterbrook, 1946)

Green MEP, Molly Cato, describes how she has lost count of the times she has debated the "Armageddon" we are inflicting on our environment, only to be met with "patient, patronising smiles" from fellow MEPs and no action.

The quote above comes from a 1946 article and refers to DDT and other contemporary "powerful insecticides of which far too little is yet known". The author goes on to liken those humans intent on spreading pesticides through their own environment to "schoolboys rat-hunting in a munitions dump with a flame thrower".

Note. DDT was the first modern synthetic insecticide. Its insecticidal properties were discovered in 1939 and it was quickly adopted by the military in World War II to protect the troops. The scientists who identified DDT's pesticidal potential won the Nobel prize for it. DDT has been poisoning the world ever since.

Since then, we've had decades of the Green Revolution inflicting chemical after chemical on our world, and now we have GM crops specially designed for greater chemical applications, and even for producing their own.

Our CRISPR food future

March 2019

DuPont Pioneer scientists published a paper in 2017 which gives an insight into where the biotech crop market is planning to go next. This study demonstrated the "utility" of the CRISPR-Cas9 system [1] in editing maize DNA for breeding drought-tolerant crops.

The study focused on a 'key' gene which controls stress tolerance in maize by altering the plant's sensitivity to the plant hormone, ethylene. When this gene is active, the cells of the plant get bigger and multiply more. Under stress, however, plants tend to conserve their resources, the gene is switched off, and growth is reduced. By adding an artificial 'on-switch', promoter 'ARGOS8', the gene can be rendered uncontrollably over-active, thus overcoming the plant's natural reaction and increasing the yield despite the adverse environmental conditions. Enter the CRISPR-Cas9 trick to insert an artificial version of the ARGOS8 promoter DNA.

Cost-cutting in Brazil

November 2018

In 2016, organic food sales in Brazil were mushrooming by 20 to 30 percent a year.  At the same time, some 70 percent of organic produce was being exported to Europe.  Farmers there recognise that "Growing organics is the future", and the people are increasingly "wanting healthier food free from pesticides".

Were it not for the alliance between the government and Big Agriculture, which is driving the economy, and the supermarkets, which are controlling the food supply system, organics would be a key growth industry.  Instead, it remains a tiny fraction of the whole, swamped by Big Ag's desire for GM crops and their supporting chemicals.  Supermarkets, of course, promote cut-throat competition amongst their suppliers, and the 'winners' are the unrestrained fraudsters passing off conventional pesticide-laden food as 'organic'.

Faced with this scenario, the Brazilian government is busy pushing through two far-reaching pieces of legislation.

USA missing the main markets

October 2018

America has been gung-ho about declaring gene-edited plants somehow not really GM, paving the way for the new-GM crops now lining up for entry to the US food market [1,2].

The back-drop to this is interesting.

Organic food is a safe choice

November 2017

In the face of growing concerns that our current chemical-dependent food production systems are neither sustainable nor healthy, the European Parliament has commissioned a review of the scientific evidence of the impact of chemical-free, organic food production (see Note below).

The evidence available for review was sparse, lacking in direct human health or long-term studies, limited by reductionist data, and absent mechanistic explanations for results. In particular, the reviewers led by Swedish University of Agriculture scientists, reported that epidemiological surveys have had a very low impact on regulatory assessments despite involving real-life exposure to multiple chemicals and whole human populations.

One important, but side-lined, US population study linked pesticide levels in the mothers' body (assessed from urine levels) with impaired cognitive development in their children.

Glyphosate causes crop disease

June 2017

In 2003, during a 5-year study of crop disease, the first alarm was raised that wheat appeared to be worse affected by 'fusarium head blight' in fields where glyphosate herbicide had been applied just before planting. Laboratory studies at the time also indicated that fusarium grows faster when glyphosate-based weedkillers are added to the medium they're growing in.

Fusarium head blight is a devastating fungal disease which destroys a fifth of wheat harvests in Europe alone. This fungus produces 'mycotoxins' (poisons) known to cause cancer of the liver and kidney, disorders of the blood and lung, vomiting, and damage to the immune system. Anything which promotes fusarium is a serious business.

Glyphosate infusion into the world

October 2016

Photo Creative Commons

Glyphosate herbicide usage has got so out of control, it seems to have taken on a life of its own.

Most of the livestock which provide us with our meat, dairy and eggs are fed maize, soya and cotton seed. Most of these three crops are liberally sprayed with glyphosate because they've been genetically transformed to accumulate this weedkiller.

Livestock aren't the only animals eating GM crops. Bees can forage over several miles, and monocultures of GM maize, soya, cotton, and oilseed rape in flower provide a bees' banquet. Hardly surprising then that American honey is ubiquitously contaminated with the herbicide.

GMO free Russia

August 2016

Russian market. Photo Creative Commons

Over the past two years, Russia has chosen its path forward.

While America is pouring its agri-energy into feeding the global market, especially with GMOs, and trying to get everyone else to do the same, Russia has set itself some very different goals.

By 2020, it aims to fully meet the Russian demand for locally produced Russian food. 

GM and tadpoles don't mix

May 2016

'Bt' toxins are a favourite tool of genetic engineers for creating crops which generate their own pesticide to kill whatever is their most troublesome insect pest.

In Nature, such toxins are formed by a variety of strains of Bacillus thuringienses bacteria (hence 'Bt') found in soil and on plants. Organic farmers may use Bacillus thrunigienses fermentations as natural, short-lived insecticide sprays on their crops. Outside of organic agriculture however, Bt-toxin containing formula are used to control specific problematic insects, such as disease-carrying mosquitoes.

Organic farmers pay the price of GM

April 2016

While America wakes up and finds itself with a GM alfalfa pollution problem [1], and Spain scrambles to control its GM maize pollution problem [2], the UK has just found itself with a GM oilseed rape which nearly became a pollution problem.

Britain doesn't, of course, grow GM anything commercially.  The offending genes were found during routine trials of seeds seeking new plant variety registration.  DEFRA quickly recalled the seeds, and ensured that all affected plants will be destroyed by the company which supplied them.  Mysteriously, the seed was imported from France which doesn't grow GM oilseed rape either.

A grass going feral and becoming a conduit for gene contamination is predictable [1].  An invasive gene-transmitting weed from the other side of the world in today's globalised market [2] is something we have to start watching out for.  The possible pollution of our entire seed supply is simply stupidity.

The problems caused by GM contamination aren't abstract or ideological threats. 

Real-life GM alfalfa contamination

April 2016

The GM alfalfa grass saga continues ... [1]

The US Department of Agriculture (USDA) has long maintained that GM crops can co-exist with conventional and organic agriculture.  To keep GMOs in the field where they've been planted, all that's needed is for neighbouring farmers to sort things out between themselves, follow "best management practice", and sue each other if things go wrong. 

But, GM alfalfa, is blowing that narrative apart.

US food trends going into 2016

February 2016

 

It became increasingly obvious during 2015 that eating habits across the USA are changing.

 

For today's Americans, all those processed, packaged offerings on the grocery shelves are conjuring up images of Michael Pollan's 'food-like substances' stripped of their nutrition, and loaded with chemicals and sugar. Consumers are demanding fresh, local, organic food.

 

After decades of foisting ever-cheaper, and ever-more-artificial fare on the public using deceptive marketing, corporate-sponsored research and government lobbying, food manufacturers are finding that their erstwhile customers are walking away from the country's most iconic food brands. Big brand names are fast becoming liabilities.